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KMID : 0370219810250010037
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Yakhak Hoeji
1981 Volume.25 No. 1 p.37 ~ p.42
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Stability Analysis of Ampicillin Trihydrate in Solid-State
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김종국/Kim CK
곽효성/신희종/Kwak HS/Shin HJ
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Abstract
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Penicillin derivatives have a stability problem by hydrolysis of their beta-lactam ring. At high temperature, crystal water is released from penicillin derivatives, especially ampicillin trihydrate and concerns itself in hydrolysis. Penicillin derivatives having crystal water show different crystal states and different stability according to the variation of different condition on the process of manufacturing. The stability of ampicillin trihydrate in solid states was determined. Physico-pharmaceutical properties of this compound were determined by using IR spectra, X-ray powder diffraction and differential thermal analysis (DTA).
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